Rab2A is a pivotal switch protein that promotes either secretion or ER-associated degradation of (pro)insulin in insulin-secreting cells

Rab2A, a small GTPase localizing to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC), regulates COPI-dependent vesicular transport from the ERGIC. Rab2A knockdown inhibited glucose-stimulated insulin secretion and concomitantly enlarged the ERGIC in insulin-secreting cells. Larg...

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Detalles Bibliográficos
Autores principales: Sugawara, Taichi, Kano, Fumi, Murata, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381769/
https://www.ncbi.nlm.nih.gov/pubmed/25377857
http://dx.doi.org/10.1038/srep06952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381769/
https://www.ncbi.nlm.nih.gov/pubmed/25377857
http://dx.doi.org/10.1038/srep06952

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