Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening

Structure based drug discovery on GPCRs harness atomic detail X-ray binding pockets and large libraries of potential drug lead candidates in virtual screening (VS) to identify novel lead candidates. Relatively small conformational differences between such binding pockets can be critical to the succe...

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Detalles Bibliográficos
Autores principales: Coudrat, Thomas, Christopoulos, Arthur, Sexton, Patrick Michael, Wootten, Denise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381884/
https://www.ncbi.nlm.nih.gov/pubmed/28380046
http://dx.doi.org/10.1371/journal.pone.0174719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381884/
https://www.ncbi.nlm.nih.gov/pubmed/28380046
http://dx.doi.org/10.1371/journal.pone.0174719

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