Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin

The broad-spectrum anthelmintic drug ivermectin (IVM) activates and stabilizes an open-channel conformation of invertebrate chloride-selective glutamate receptors (GluClRs), thereby causing a continuous inflow of chloride ions and sustained membrane hyperpolarization. These effects suppress nervous...

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Detalles Bibliográficos
Autores principales: Degani-Katzav, Nurit, Gortler, Revital, Weissman, Marina, Paas, Yoav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382172/
https://www.ncbi.nlm.nih.gov/pubmed/28428744
http://dx.doi.org/10.3389/fnmol.2017.00092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382172/
https://www.ncbi.nlm.nih.gov/pubmed/28428744
http://dx.doi.org/10.3389/fnmol.2017.00092

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