Cargando…

Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet

AMP-activated protein kinase (AMPK) plays a key role in integrating metabolic pathways in response to energy demand. We identified a mutation in the γ1 subunit (γ1(D316A)) that leads to activation of AMPK. We generated mice with this mutation to study the effect of chronic liver-specific activation...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woods, Angela, Williams, Jennet R., Muckett, Phillip J., Mayer, Faith V., Liljevald, Maria, Bohlooly-Y, Mohammad, Carling, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382239/ https://www.ncbi.nlm.nih.gov/pubmed/28355557 http://dx.doi.org/10.1016/j.celrep.2017.03.011

Ejemplares similares

AMPK activation protects against diet induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue
por: Pollard, Alice E., et al.
Publicado: (2019)

Neurosecretory Protein GL Accelerates Liver Steatosis in Mice Fed Medium-Fat/Medium-Fructose Diet
por: Narimatsu, Yuki, et al.
Publicado: (2022)

LKB1 Is an Essential Regulator of Spermatozoa Release during Spermiation in the Mammalian Testis
por: Denison, Fiona C., et al.
Publicado: (2011)

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways
por: Li, Yu-Cheng, et al.
Publicado: (2018)

WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1
por: Zheng, Zhe, et al.
Publicado: (2021)

AMPK activation protects against prostate cancer by inducing a catabolic cellular state
por: Penfold, Lucy, et al.
Publicado: (2023)

Gut microbiota induces hepatic steatosis by modulating the T cells balance in high fructose diet mice
por: Zhou, Xiaoqiong, et al.
Publicado: (2023)

Sitagliptin can inhibit the development of hepatic steatosis in high-fructose diet-fed ob/ob mice
por: Sujishi, Tetsuya, et al.
Publicado: (2015)

Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial
por: Simons, Nynke, et al.
Publicado: (2020)

High-fructose feeding does not induce steatosis or non-alcoholic fatty liver disease in pigs
por: Schmidt, Nikolaj H., et al.
Publicado: (2021)

Integrative analysis of transcriptome and lipidome reveals fructose pro-steatosis mechanism in goose fatty liver
por: Wei, Rongxue, et al.
Publicado: (2023)

SGLT5 Reabsorbs Fructose in the Kidney but Its Deficiency Paradoxically Exacerbates Hepatic Steatosis Induced by Fructose
por: Fukuzawa, Taku, et al.
Publicado: (2013)

Liver and Metformin: Lessons of a fructose diet in mice
por: Karise, Iara, et al.
Publicado: (2017)

High-fructose diet initially promotes increased aortic wall thickness, liver steatosis, and cardiac histopathology deterioration, but does not increase body fat index
por: Handayani, Dian, et al.
Publicado: (2021)

Involvement of 5′AMP-Activated Protein Kinase (AMPK) in the Effects of Resveratrol on Liver Steatosis
por: Trepiana, Jenifer, et al.
Publicado: (2018)

Lactobacillus Strains Alleviated Hyperlipidemia and Liver Steatosis in Aging Rats via Activation of AMPK
por: Lew, Lee-Ching, et al.
Publicado: (2020)

Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice
por: Van Herck, Mikhaïl A., et al.
Publicado: (2020)

β-catenin mediates the effect of GLP-1 receptor agonist on ameliorating hepatic steatosis induced by high fructose diet
por: Gao, Zhe, et al.
Publicado: (2020)

Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis
por: Shepherd, Emma L., et al.
Publicado: (2020)

The Effects of Probiotics and Omega-3 Fatty Acids in Liver Steatosis Induced in Rats by High-Fructose Corn Syrup
por: Kizilaslan, Nildem, et al.
Publicado: (2022)

Hyperglycemia-stimulating diet induces liver steatosis in sheep
por: Kalyesubula, Mugagga, et al.
Publicado: (2020)

Fructose and the Liver
por: Muriel, Pablo, et al.
Publicado: (2021)

Short-Term Intake of a Fructose-, Fat- and Cholesterol-Rich Diet Causes Hepatic Steatosis in Mice: Effect of Antibiotic Treatment
por: Brandt, Annette, et al.
Publicado: (2017)

A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats
por: Yustisia, Ika, et al.
Publicado: (2022)

Folic acid supplementation prevents high fructose-induced non-alcoholic fatty liver disease by activating the AMPK and LKB1 signaling pathways
por: Kim, Hyewon, et al.
Publicado: (2020)

Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
por: Huang, Wan, et al.
Publicado: (2010)

Polyacetylene From Dendropanax morbifera Alleviates Diet-Induced Obesity and Hepatic Steatosis by Activating AMPK Signaling Pathway
por: Kang, Myung-Ji, et al.
Publicado: (2018)

Probiotics counteract hepatic steatosis caused by ketogenic diet and upregulate AMPK signaling in a model of infantile epilepsy
por: Mu, Chunlong, et al.
Publicado: (2022)

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK
por: Zhang, Chen-Song, et al.
Publicado: (2017)

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
por: Garcia, Daniel, et al.
Publicado: (2019)

Miltefosine Suppresses Hepatic Steatosis by Activating AMPK Signal Pathway
por: Fang, Ru, et al.
Publicado: (2016)

Parenteral Nutrition Associated Hepatic Steatosis and NAFLD Intersect at AMPK
por: Guthrie, Gregory
Publicado: (2022)

AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development
por: Boudaba, Nadia, et al.
Publicado: (2018)

Fructose Diet-Induced Skin Collagen Abnormalities Are Prevented by Lipoic Acid
por: Thirunavukkarasu, V., et al.
Publicado: (2004)

Carrot Juice Administration Decreases Liver Stearoyl-CoA Desaturase 1 and Improves Docosahexaenoic Acid Levels, but Not Steatosis in High Fructose Diet-Fed Weanling Wistar Rats
por: Mahesh, Malleswarapu, et al.
Publicado: (2016)

Angiotensinogen in hepatocytes contributes to Western diet-induced liver steatosis
por: Daugherty, Alan, et al.
Publicado: (2019)

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
por: Shirakawa, Jun, et al.
Publicado: (2011)

Celiac Disease in Conjunction with Hereditary Fructose Intolerance as a Rare Cause of Liver Steatosis with Mild Hypertransaminasemia—A Case Report
por: Bobrus-Chociej, Anna, et al.
Publicado: (2021)

In Utero Dexamethasone Exposure Exacerbates Hepatic Steatosis in Rats That Consume Fructose During Adulthood
por: Payolla, Tanyara B., et al.
Publicado: (2019)

Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance
por: Edmunds, Lia R., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_74q1pq9v11umgobfrjpfk5vb1m