Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases

Glycolytic interconversion of phosphoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent mutase (iPGM) structurally distinct from the mammalian cofactor-dependent (dPGM) isozyme. The iPGM active site dynamically assembles through substrate-triggered movemen...

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Detalles Bibliográficos
Autores principales: Yu, Hao, Dranchak, Patricia, Li, Zhiru, MacArthur, Ryan, Munson, Matthew S., Mehzabeen, Nurjahan, Baird, Nathan J., Battalie, Kevin P., Ross, David, Lovell, Scott, Carlow, Clotilde K. S., Suga, Hiroaki, Inglese, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382265/
https://www.ncbi.nlm.nih.gov/pubmed/28368002
http://dx.doi.org/10.1038/ncomms14932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382265/
https://www.ncbi.nlm.nih.gov/pubmed/28368002
http://dx.doi.org/10.1038/ncomms14932

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