Biomimetic catalytic transformation of toxic α-oxoaldehydes to high-value chiral α-hydroxythioesters using artificial glyoxalase I

Glyoxalase I plays a critical role in the enzymatic defence against glycation by catalysing the isomerization of hemithioacetal, formed spontaneously from cytotoxic α-oxoaldehydes and glutathione, to (S)-α-hydroxyacylglutathione derivatives. Upon the hydrolysis of the thioesters catalysed by glyoxal...

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Detalles Bibliográficos
Autores principales: Park, Sang Yeon, Hwang, In-Soo, Lee, Hyun-Ju, Song, Choong Eui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382281/
https://www.ncbi.nlm.nih.gov/pubmed/28374736
http://dx.doi.org/10.1038/ncomms14877

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382281/
https://www.ncbi.nlm.nih.gov/pubmed/28374736
http://dx.doi.org/10.1038/ncomms14877

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