Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes

BACKGROUND: Brain p38α mitogen-activated protein kinase (MAPK), a potential therapeutic target for cognitive dysfunction based on the neuroinflammation-synaptic dysfunction cycle of pathophysiology progression, offers an innovative pharmacological strategy via inhibiting the same activated target in...

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Detalles Bibliográficos
Autores principales: Zhou, Zhengqiu, Bachstetter, Adam D., Späni, Claudia B., Roy, Saktimayee M., Watterson, D. Martin, Van Eldik, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382362/
https://www.ncbi.nlm.nih.gov/pubmed/28381303
http://dx.doi.org/10.1186/s12974-017-0845-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382362/
https://www.ncbi.nlm.nih.gov/pubmed/28381303
http://dx.doi.org/10.1186/s12974-017-0845-2

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