The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism

In the present work we performed a combined experimental and computational study on the interaction of the natural antimalarial endoperoxide plakortin and its synthetic analogue 4a with heme. Obtained results indicate that the studied compounds produce reactive carbon radical species after being red...

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Detalles Bibliográficos
Autores principales: Persico, Marco, Fattorusso, Roberto, Taglialatela-Scafati, Orazio, Chianese, Giuseppina, de Paola, Ivan, Zaccaro, Laura, Rondinelli, Francesca, Lombardo, Marco, Quintavalla, Arianna, Trombini, Claudio, Fattorusso, Ernesto, Fattorusso, Caterina, Farina, Biancamaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382535/
https://www.ncbi.nlm.nih.gov/pubmed/28383076
http://dx.doi.org/10.1038/srep45485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382535/
https://www.ncbi.nlm.nih.gov/pubmed/28383076
http://dx.doi.org/10.1038/srep45485

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