Long-term treatment with intranasal insulin ameliorates cognitive impairment, tau hyperphosphorylation, and microglial activation in a streptozotocin-induced Alzheimer’s rat model

Recent evidence reveals that aberrant brain insulin signaling plays an important role in the pathology of Alzheimer’s disease (AD). Intranasal insulin administration has been reported to improve memory and attention in healthy participants and in AD patients. However, the underlying molecular mechan...

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Detalles Bibliográficos
Autores principales: Guo, Zhangyu, Chen, Yanxing, Mao, Yan-Fang, Zheng, Tingting, Jiang, Yasi, Yan, Yaping, Yin, Xinzhen, Zhang, Baorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382700/
https://www.ncbi.nlm.nih.gov/pubmed/28382978
http://dx.doi.org/10.1038/srep45971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382700/
https://www.ncbi.nlm.nih.gov/pubmed/28382978
http://dx.doi.org/10.1038/srep45971

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