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A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease

Oxidation of methionine residues to methionine sulfoxide (MetSO) may cause changes in protein structure and function, and may eventually lead to cell damage. Methionine sulfoxide reductases (Msrs) are the only known enzymes that catalyze the reduction of MetSO back to methionine by taking reducing e...

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Detalles Bibliográficos
Autores principales: Zhang, Liangwei, Peng, Shoujiao, Sun, Jinyu, Yao, Juan, Kang, Jie, Hu, Yuesong, Fang, Jianguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382841/
https://www.ncbi.nlm.nih.gov/pubmed/28451363
http://dx.doi.org/10.1039/c6sc04708d