A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction

Mutations in the gene encoding tau (MAPT) cause frontotemporal dementia spectrum disorders. A rare tau variant p.A152T was reported as a risk factor for frontotemporal dementia spectrum and Alzheimer’s disease in an initial case-control study. Such findings need replication in an independent cohort....

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Detalles Bibliográficos
Autores principales: Lopez, Ana, Lee, Suzee E., Wojta, Kevin, Ramos, Eliana Marisa, Klein, Eric, Chen, Jason, Boxer, Adam L., Gorno-Tempini, Maria Luisa, Geschwind, Daniel H., Schlotawa, Lars, Ogryzko, Nikolay V., Bigio, Eileen H., Rogalski, Emily, Weintraub, Sandra, Mesulam, Marsel M., Fleming, Angeleen, Coppola, Giovanni, Miller, Bruce L., Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382950/
https://www.ncbi.nlm.nih.gov/pubmed/28334843
http://dx.doi.org/10.1093/brain/awx005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382950/
https://www.ncbi.nlm.nih.gov/pubmed/28334843
http://dx.doi.org/10.1093/brain/awx005

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