Trehalose dimycolate interferes with FcγR-mediated phagosome maturation through Mincle, SHP-1 and FcγRIIB signalling

The causative agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), contains an abundant cell wall glycolipid and a crucial virulence factor, trehalose-6,6’-dimycolate (TDM). TDM causes delay of phagosome maturation and thus promotes survival of mycobacteria inside host macrophages by...

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Detalles Bibliográficos
Autores principales: Patin, Emmanuel C., Geffken, Anna C., Willcocks, Sam, Leschczyk, Christoph, Haas, Albert, Nimmerjahn, Falk, Lang, Roland, Ward, Theresa H., Schaible, Ulrich E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383150/
https://www.ncbi.nlm.nih.gov/pubmed/28384255
http://dx.doi.org/10.1371/journal.pone.0174973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383150/
https://www.ncbi.nlm.nih.gov/pubmed/28384255
http://dx.doi.org/10.1371/journal.pone.0174973

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