Deep mutational scanning identifies sites in influenza nucleoprotein that affect viral inhibition by MxA

The innate-immune restriction factor MxA inhibits influenza replication by targeting the viral nucleoprotein (NP). Human influenza virus is more resistant than avian influenza virus to inhibition by human MxA, and prior work has compared human and avian viral strains to identify amino-acid differenc...

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Detalles Bibliográficos
Autores principales: Ashenberg, Orr, Padmakumar, Jai, Doud, Michael B., Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383324/
https://www.ncbi.nlm.nih.gov/pubmed/28346537
http://dx.doi.org/10.1371/journal.ppat.1006288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383324/
https://www.ncbi.nlm.nih.gov/pubmed/28346537
http://dx.doi.org/10.1371/journal.ppat.1006288

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