Proton and non-proton activation of ASIC channels

The Acid-Sensing Ion Channels (ASIC) exhibit a fast desensitizing current when activated by pH values below 7.0. By contrast, non-proton ligands are able to trigger sustained ASIC currents at physiological pHs. To analyze the functional basis of the ASIC desensitizing and sustained currents, we have...

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Detalles Bibliográficos
Autores principales: Gautschi, Ivan, van Bemmelen, Miguel Xavier, Schild, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383329/
https://www.ncbi.nlm.nih.gov/pubmed/28384246
http://dx.doi.org/10.1371/journal.pone.0175293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383329/
https://www.ncbi.nlm.nih.gov/pubmed/28384246
http://dx.doi.org/10.1371/journal.pone.0175293

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