Kinesin-4 KIF21B is a potent microtubule pausing factor

Microtubules are dynamic polymers that in cells can grow, shrink or pause, but the factors that promote pausing are poorly understood. Here, we show that the mammalian kinesin-4 KIF21B is a processive motor that can accumulate at microtubule plus ends and induce pausing. A few KIF21B molecules are s...

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Detalles Bibliográficos
Autores principales: van Riel, Wilhelmina E, Rai, Ankit, Bianchi, Sarah, Katrukha, Eugene A, Liu, Qingyang, Heck, Albert JR, Hoogenraad, Casper C, Steinmetz, Michel O, Kapitein, Lukas C, Akhmanova, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383399/
https://www.ncbi.nlm.nih.gov/pubmed/28290984
http://dx.doi.org/10.7554/eLife.24746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383399/
https://www.ncbi.nlm.nih.gov/pubmed/28290984
http://dx.doi.org/10.7554/eLife.24746

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