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Regulation of the JMJD3 (KDM6B) histone demethylase in glioblastoma stem cells by STAT3
The growth factor and cytokine regulated transcription factor STAT3 is required for the self-renewal of several stem cell types including tumor stem cells from glioblastoma. Here we show that STAT3 inhibition leads to the upregulation of the histone H3K27me2/3 demethylase Jmjd3 (KDM6B), which can re...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383422/ https://www.ncbi.nlm.nih.gov/pubmed/28384648 http://dx.doi.org/10.1371/journal.pone.0174775 |