Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction

Cancer cells depend on glutamine to sustain their increased proliferation and manage oxidative stress, yet glutamine is often depleted at tumor sites due to excessive cellular consumption and poor vascularization. We have previously reported that p53 protein, while a well-known tumor suppressor, can...

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Detalles Bibliográficos
Autores principales: Tran, Thai Q., Lowman, Xazmin H., Reid, Michael A., Mendez-Dorantes, Carlos, Pan, Min, Yang, Ying, Kong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383530/
https://www.ncbi.nlm.nih.gov/pubmed/27721412
http://dx.doi.org/10.1038/onc.2016.360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383530/
https://www.ncbi.nlm.nih.gov/pubmed/27721412
http://dx.doi.org/10.1038/onc.2016.360

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