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Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction
Cancer cells depend on glutamine to sustain their increased proliferation and manage oxidative stress, yet glutamine is often depleted at tumor sites due to excessive cellular consumption and poor vascularization. We have previously reported that p53 protein, while a well-known tumor suppressor, can...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383530/ https://www.ncbi.nlm.nih.gov/pubmed/27721412 http://dx.doi.org/10.1038/onc.2016.360 |