The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities

Phosphodiesterase regulates the homeostasis of cAMP and cGMP, which increase the strength of excitatory neural circuits and/or decrease inhibitory synaptic plasticity. Abnormally, synchronized synaptic transmission in the brain leads to seizures. A phosphodiesterase 10A (PDE10A) inhibitor PF-2545920...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yanke, Gao, Baobing, Zheng, Fangshuo, Lu, Shanshan, Li, Yun, Xiong, Yan, Yang, Qin, Yang, Yong, Fu, Pengfei, Xiao, Fei, Wang, Xuefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383654/
https://www.ncbi.nlm.nih.gov/pubmed/28439226
http://dx.doi.org/10.3389/fnmol.2017.00100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383654/
https://www.ncbi.nlm.nih.gov/pubmed/28439226
http://dx.doi.org/10.3389/fnmol.2017.00100

Ejemplares similares