Cargando…

The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities

Phosphodiesterase regulates the homeostasis of cAMP and cGMP, which increase the strength of excitatory neural circuits and/or decrease inhibitory synaptic plasticity. Abnormally, synchronized synaptic transmission in the brain leads to seizures. A phosphodiesterase 10A (PDE10A) inhibitor PF-2545920...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yanke, Gao, Baobing, Zheng, Fangshuo, Lu, Shanshan, Li, Yun, Xiong, Yan, Yang, Qin, Yang, Yong, Fu, Pengfei, Xiao, Fei, Wang, Xuefeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383654/ https://www.ncbi.nlm.nih.gov/pubmed/28439226 http://dx.doi.org/10.3389/fnmol.2017.00100

Ejemplares similares

Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility
por: Yang, Yi-Ting, et al.
Publicado: (2023)

NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B
por: Zhang, Yanke, et al.
Publicado: (2016)

Corrigendum: NR4A1 Knockdown Suppresses Seizure Activity by Regulating Surface Expression of NR2B
por: Zhang, Yanke, et al.
Publicado: (2017)

Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex
por: Toyoda, Hiroki, et al.
Publicado: (2009)

Synaptic plasticity through activation of GluA3-containing AMPA-receptors
por: Renner, Maria C, et al.
Publicado: (2017)

GluA3 subunits are required for appropriate assembly of AMPAR GluA2 and GluA4 subunits on cochlear afferent synapses and for presynaptic ribbon modiolar–pillar morphology
por: Rutherford, Mark A, et al.
Publicado: (2023)

Neurobiology of rapid acting antidepressants: convergent effects on GluA1-synaptic function
por: Duman, Ronald S., et al.
Publicado: (2019)

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation
por: Widagdo, Jocelyn, et al.
Publicado: (2015)

Emerging role of AMPA receptor subunit GluA1 in synaptic plasticity: Implications for Alzheimer's disease
por: Qu, Wenrui, et al.
Publicado: (2020)

AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability
por: Lykens, Nicole M., et al.
Publicado: (2017)

R/G editing in GluA2R(flop) modulates the functional difference between GluA1 flip and flop variants in GluA1/2R heteromeric channels
por: Wen, Wei, et al.
Publicado: (2017)

SAPAP3 regulates epileptic seizures involving GluN2A in post-synaptic densities
por: Zhang, Yanke, et al.
Publicado: (2022)

Postsynaptic VAMP/Synaptobrevin Facilitates Differential Vesicle Trafficking of GluA1 and GluA2 AMPA Receptor Subunits
por: Hussain, Suleman, et al.
Publicado: (2015)

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition
por: van der Spek, Sophie J. F., et al.
Publicado: (2022)

ABA Renewal Involves Enhancements in Both GluA2-Lacking AMPA Receptor Activity and GluA1 Phosphorylation in the Lateral Amygdala
por: Park, Kyungjoon, et al.
Publicado: (2014)

Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives
por: Qneibi, Mohammad, et al.
Publicado: (2019)

p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
por: Li, Jia-Bing, et al.
Publicado: (2023)

Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus
por: Romberg, Carola, et al.
Publicado: (2009)

Extracellular Cyclic GMP Modulates Membrane Expression of The GluA1 and GluA2 Subunits of AMPA Receptor in Cerebellum: Molecular Mechanisms Involved
por: Cabrera-Pastor, Andrea, et al.
Publicado: (2017)

Investigation of GluA1 and GluA2 AMPA receptor subtype distribution in the hippocampus and anterior cingulate cortex of Long Evans rats during development
por: Tzakis, Nikolaos, et al.
Publicado: (2020)

Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease
por: Gu, Xunhu, et al.
Publicado: (2021)

Motor Learning Requires Purkinje Cell Synaptic Potentiation through Activation of AMPA-Receptor Subunit GluA3
por: Gutierrez-Castellanos, Nicolas, et al.
Publicado: (2017)

Proline‐rich transmembrane protein 2 specifically binds to GluA1 but has no effect on AMPA receptor‐mediated synaptic transmission
por: Feng, Hao‐Yang, et al.
Publicado: (2022)

The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells
por: Rubio, María E., et al.
Publicado: (2017)

Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms
por: Taoro-Gonzalez, Lucas, et al.
Publicado: (2018)

The Inhibitory Effect of α/β-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors
por: Wei, Mengping, et al.
Publicado: (2017)

Mutually Dependent Clustering of SynDIG4/PRRT1 and AMPA Receptor Subunits GluA1 and GluA2 in Heterologous Cells and Primary Neurons
por: Plambeck, Kristopher E., et al.
Publicado: (2022)

Synaptic remodeling of GluA1 and GluA2 expression in the nucleus accumbens promotes susceptibility to cognitive deficits concomitant with downstream GSK3β mediated neurotoxicity in female mice during abstinence from voluntary oral methamphetamine
por: Memos, Nicoletta, et al.
Publicado: (2023)

GluA1 Phosphorylation Alters Evoked Firing Pattern In Vivo
por: Barkóczi, Balázs, et al.
Publicado: (2012)

PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal excitability via GluA1 ubiquitination
por: Kim, Ji-Eun, et al.
Publicado: (2019)

Synaptically Released Matrix Metalloproteinase Activity in Control of Structural Plasticity and the Cell Surface Distribution of GluA1-AMPA Receptors
por: Szepesi, Zsuzsanna, et al.
Publicado: (2014)

Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model
por: Lim, Chae-Seok, et al.
Publicado: (2014)

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition
por: Mignogna, Maria Lidia, et al.
Publicado: (2015)

Nitric Oxide Regulates GluA2-Lacking AMPAR Contribution to Synaptic Transmission of CA1 Apical but Not Basal Dendrites
por: Ivanova, Violetta O., et al.
Publicado: (2021)

GPR40 modulates epileptic seizure and NMDA receptor function
por: Yang, Yong, et al.
Publicado: (2018)

Analysis of the Potential Role of GluA4 Carboxyl-Terminus in PDZ Interactions
por: Coleman, Sarah K., et al.
Publicado: (2010)

ADAR2-dependent GluA2 editing regulates cocaine seeking
por: Schmidt, H.D., et al.
Publicado: (2014)

Disrupting GluA2-GAPDH Interaction Affects Axon and Dendrite Development
por: Lee, Frankie Hang Fung, et al.
Publicado: (2016)

PKN1 Is a Novel Regulator of Hippocampal GluA1 Levels
por: Safari, Motahareh Solina, et al.
Publicado: (2021)

GluA2 overexpression in oligodendrocyte progenitors promotes postinjury oligodendrocyte regeneration
por: Khawaja, Rabia R., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_po5cj9o8utvonnqkilshlip9qk