A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Most myeloproliferative neoplasm (MPN) patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells, we developed a novel strategy (KISMET) that utili...

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Detalles Bibliográficos
Autores principales: Kollmann, K, Warsch, W, Gonzalez-Arias, C, Nice, F L, Avezov, E, Milburn, J, Li, J, Dimitropoulou, D, Biddie, S, Wang, M, Poynton, E, Colzani, M, Tijssen, M R, Anand, S, McDermott, U, Huntly, B, Green, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383931/
https://www.ncbi.nlm.nih.gov/pubmed/27740635
http://dx.doi.org/10.1038/leu.2016.280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383931/
https://www.ncbi.nlm.nih.gov/pubmed/27740635
http://dx.doi.org/10.1038/leu.2016.280

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