Cargando…

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation

Most myeloproliferative neoplasm (MPN) patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear. To identify kinases important for survival of CALR-mutant cells, we developed a novel strategy (KISMET) that utili...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kollmann, K, Warsch, W, Gonzalez-Arias, C, Nice, F L, Avezov, E, Milburn, J, Li, J, Dimitropoulou, D, Biddie, S, Wang, M, Poynton, E, Colzani, M, Tijssen, M R, Anand, S, McDermott, U, Huntly, B, Green, T
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383931/ https://www.ncbi.nlm.nih.gov/pubmed/27740635 http://dx.doi.org/10.1038/leu.2016.280

Ejemplares similares

MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling
por: Kollmann, K, et al.
Publicado: (2015)

CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes
por: Olschok, Kathrin, et al.
Publicado: (2021)

Pleomorphic circulating megakaryocytes in a case of CALR positive primary myelofibrosis in leukemic transformation
por: Moshref Razavi, Habib
Publicado: (2021)

Megakaryocytes, erythropoietic and granulopoietic cells express CAL2 antibody in myeloproliferative neoplasms carrying CALR gene mutations
por: Ali, Hebah, et al.
Publicado: (2020)

Brain-derived Neurotrophic Factor in Megakaryocytes
por: Chacón-Fernández, Pedro, et al.
Publicado: (2016)

Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis
por: Shide, Kotaro, et al.
Publicado: (2019)

Allelic imbalance in CALR somatic mutagenesis
por: Harutyunyan, A S, et al.
Publicado: (2015)

CALR mutation characterization in myeloproliferative neoplasms
por: Bilbao-Sieyro, Cristina, et al.
Publicado: (2016)

CALR Mutation Underlying Silent Stroke
por: Faryal, Rehman, et al.
Publicado: (2021)

Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program
por: Park, Hyun Jung, et al.
Publicado: (2015)

Clonal independence of JAK2 and CALR or MPL mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing
por: Thompson, Ella R., et al.
Publicado: (2020)

Calreticulin (CALR)-induced activation of NF-ĸB signaling pathway boosts lung cancer cell proliferation
por: Gao, Fangfang, et al.
Publicado: (2022)

The Contemporary Approach to CALR-Positive Myeloproliferative Neoplasms
por: Belčič Mikič, Tanja, et al.
Publicado: (2021)

CALR mutations in myeloproliferative neoplasms: An unfolding story
por: Langabeer, Stephen E.
Publicado: (2020)

Bioinformatics analysis for the role of CALR in human cancers
por: Li, Yijun, et al.
Publicado: (2021)

Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
por: Moreau, Thomas, et al.
Publicado: (2016)

Dynamic regulation of glucocorticoid signalling in health and disease
por: Biddie, Simon C., et al.
Publicado: (2012)

Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling
por: Moore, Samantha F., et al.
Publicado: (2015)

Corrigendum: Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming
por: Moreau, Thomas, et al.
Publicado: (2017)

Human megakaryocytes. V. Changes in the phenotypic profile of differentiating megakaryocytes
Publicado: (1985)

Hungry megakaryocytes on the hunt? An unusual case of extensive megakaryocyte emperipolesis
por: Vijaya Devi, S., et al.
Publicado: (2021)

Thrombopoietin receptor is required for the oncogenic function of CALR mutants
por: Nivarthi, H, et al.
Publicado: (2016)

Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling
por: Wales, Stephanie, et al.
Publicado: (2014)

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet
por: Molina-Ortiz, Patricia, et al.
Publicado: (2014)

Gfi1b controls integrin signaling-dependent cytoskeleton dynamics and organization in megakaryocytes
por: Beauchemin, Hugues, et al.
Publicado: (2017)

Lack of evidence for a causal role of CALR3 in monogenic cardiomyopathy
por: Verhagen, Judith M. A., et al.
Publicado: (2018)

Activation of the Nkx2.5–Calr–p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish
por: Sun, Yanyi, et al.
Publicado: (2017)

STORAGE OF 5-HYDROXYTRYPTAMINE IN MEGAKARYOCYTES
por: Tranzer, J. P., et al.
Publicado: (1972)

Human megakaryocytes. II. Expression of platelet proteins in early marrow megakaryocytes
Publicado: (1981)

Phenotypic correlations of CALR mutation variant allele frequency in patients with myelofibrosis
por: Guglielmelli, Paola, et al.
Publicado: (2023)

Acute Lymphoblastic Leukemia Arising in CALR Mutated Essential Thrombocythemia
por: Langabeer, Stephen E., et al.
Publicado: (2016)

Expression of CALR mutants causes mpl-dependent thrombocytosis in zebrafish
por: Lim, K-H, et al.
Publicado: (2016)

Detecting CALR Mutations in Splanchnic Vein Thrombosis: Who and How?
por: Langabeer, Stephen E.
Publicado: (2018)

Splenic mass in a case of CALR‐mutated essential thrombocythemia
por: Imashuku, Shinsaku, et al.
Publicado: (2018)

Sequential evaluation of CALR mutant burden in patients with myeloproliferative neoplasms
por: Cavalloni, Chiara, et al.
Publicado: (2017)

Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm
por: Fraiman, Yarden S, et al.
Publicado: (2016)

Concurrent chronic myeloid leukemia and CALR-mutated myeloproliferative neoplasm
por: Langabeer, Stephen E.
Publicado: (2020)

Effects of CALR-Mutant Type and Burden on the Phenotype of Myeloproliferative Neoplasms
por: Kim, Hyun-Young, et al.
Publicado: (2022)

Retinal neovascularization in the setting of CALR-mutation positive essential thrombocythemia
por: Heydinger, Stanton P, et al.
Publicado: (2023)

Understanding MAPK Signaling Pathways in Apoptosis
por: Yue, Jicheng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_as6hhk63236r032praulpp74ki