‘Hints' in the killer protein gasdermin D: unveiling the secrets of gasdermins driving cell death

Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis, necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases cleave a gasdermin D (GSDMD) protein to generate a 31 kDa N-terminal domain. The cleavage relieves the intramolecular inhi...

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Detalles Bibliográficos
Autores principales: Qiu, Shiqiao, Liu, Jing, Xing, Feiyue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384029/
https://www.ncbi.nlm.nih.gov/pubmed/28362726
http://dx.doi.org/10.1038/cdd.2017.24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384029/
https://www.ncbi.nlm.nih.gov/pubmed/28362726
http://dx.doi.org/10.1038/cdd.2017.24

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