Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice

Bone loss and increased fracture are the devastating outcomes of chronic kidney disease-mineral and bone disorder (CKD-MBD) resulting from Klotho deficit-related mineral disturbance and hyperparathyroidism. Because Klotho down-regulation after renal injury is presumably affected by aberrant histone...

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Detalles Bibliográficos
Autores principales: Lin, Wenjun, Li, Yanning, chen, Fang, Yin, Shasha, Liu, Zhihong, Cao, Wangsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384196/
https://www.ncbi.nlm.nih.gov/pubmed/28387374
http://dx.doi.org/10.1038/srep46195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384196/
https://www.ncbi.nlm.nih.gov/pubmed/28387374
http://dx.doi.org/10.1038/srep46195

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