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Klotho preservation via histone deacetylase inhibition attenuates chronic kidney disease-associated bone injury in mice

Bone loss and increased fracture are the devastating outcomes of chronic kidney disease-mineral and bone disorder (CKD-MBD) resulting from Klotho deficit-related mineral disturbance and hyperparathyroidism. Because Klotho down-regulation after renal injury is presumably affected by aberrant histone...

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Detalles Bibliográficos
Autores principales:	Lin, Wenjun, Li, Yanning, chen, Fang, Yin, Shasha, Liu, Zhihong, Cao, Wangsen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384196/ https://www.ncbi.nlm.nih.gov/pubmed/28387374 http://dx.doi.org/10.1038/srep46195

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