Highly selective inhibition of histone demethylases by de novo macrocyclic peptides

The JmjC histone demethylases (KDMs) are linked to tumour cell proliferation and are current cancer targets; however, very few highly selective inhibitors for these are available. Here we report cyclic peptide inhibitors of the KDM4A-C with selectivity over other KDMs/2OG oxygenases, including close...

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Detalles Bibliográficos
Autores principales: Kawamura, Akane, Münzel, Martin, Kojima, Tatsuya, Yapp, Clarence, Bhushan, Bhaskar, Goto, Yuki, Tumber, Anthony, Katoh, Takayuki, King, Oliver N. F., Passioura, Toby, Walport, Louise J., Hatch, Stephanie B., Madden, Sarah, Müller, Susanne, Brennan, Paul E., Chowdhury, Rasheduzzaman, Hopkinson, Richard J., Suga, Hiroaki, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384220/
https://www.ncbi.nlm.nih.gov/pubmed/28382930
http://dx.doi.org/10.1038/ncomms14773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384220/
https://www.ncbi.nlm.nih.gov/pubmed/28382930
http://dx.doi.org/10.1038/ncomms14773

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