Calcium oxalate crystals and oxalate induce an epithelial-to-mesenchymal transition in the proximal tubular epithelial cells: Contribution to oxalate kidney injury

TGF-β1 is the main mediator of epithelial-to-mesenchymal transition (EMT). Hyperoxaluria induces crystalluria, interstitial fibrosis, and progressive renal failure. This study analyzed whether hyperoxaluria is associated with TGF-β1 production and kidney fibrosis in mice and if oxalate or calcium ox...

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Detalles Bibliográficos
Autores principales: Convento, Marcia Bastos, Pessoa, Edson Andrade, Cruz, Edgar, da Glória, Maria Aparecida, Schor, Nestor, Borges, Fernanda Teixeira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384284/
https://www.ncbi.nlm.nih.gov/pubmed/28387228
http://dx.doi.org/10.1038/srep45740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384284/
https://www.ncbi.nlm.nih.gov/pubmed/28387228
http://dx.doi.org/10.1038/srep45740

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