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Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis
The platelet-derived growth factor receptor alpha (PDGFRα) exhibits divergent effects in skeletal muscle. At physiological levels, signaling through this receptor promotes muscle development in growing embryos and proper angiogenesis in regenerating adult muscle.(1,2) However, both increased PDGF li...
Autores principales: | Mueller, Alisa A., van Velthoven, Cindy T., Fukumoto, Kathryn D., Cheung, Tom H., Rando, Thomas A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384334/ https://www.ncbi.nlm.nih.gov/pubmed/27894125 http://dx.doi.org/10.1038/nature20160 |
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