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A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation
Although several in vitro and ex vivo evidence support the existence of lactate exchange between astrocytes and neurons, a direct demonstration in vivo is still lacking. In the present study, a lentiviral vector carrying a short hairpin RNA (shRNA) was used to downregulate the expression of the mono...
Autores principales: | Mazuel, Leslie, Blanc, Jordy, Repond, Cendrine, Bouchaud, Véronique, Raffard, Gérard, Déglon, Nicole, Bonvento, Gilles, Pellerin, Luc, Bouzier-Sore, Anne-Karine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384673/ https://www.ncbi.nlm.nih.gov/pubmed/28388627 http://dx.doi.org/10.1371/journal.pone.0174990 |
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