Subunit mass analysis for monitoring antibody oxidation

Methionine oxidation is a common posttranslational modification (PTM) of monoclonal antibodies (mAbs). Oxidation can reduce the in-vivo half-life, efficacy and stability of the product. Peptide mapping is commonly used to monitor the levels of oxidation, but this is a relatively time-consuming metho...

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Detalles Bibliográficos
Autores principales: Sokolowska, Izabela, Mo, Jingjie, Dong, Jia, Lewis, Michael J., Hu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384710/
https://www.ncbi.nlm.nih.gov/pubmed/28106519
http://dx.doi.org/10.1080/19420862.2017.1279773

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384710/
https://www.ncbi.nlm.nih.gov/pubmed/28106519
http://dx.doi.org/10.1080/19420862.2017.1279773

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