Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner

There is a significantly higher risk for type II diabetes in HIV-1 carriers, albeit the molecular mechanism for this HIV-related pathology remains enigmatic. The 52 amino acid HIV-1 p6 Gag protein is synthesized as the C-terminal part of the Gag polyprotein Pr55. In this context, p6 promotes virus r...

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Detalles Bibliográficos
Autores principales: Hahn, Friedrich, Schmalen, Adrian, Setz, Christian, Friedrich, Melanie, Schlößer, Stefan, Kölle, Julia, Spranger, Robert, Rauch, Pia, Fraedrich, Kirsten, Reif, Tatjana, Karius-Fischer, Julia, Balasubramanyam, Ashok, Henklein, Petra, Fossen, Torgils, Schubert, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384750/
https://www.ncbi.nlm.nih.gov/pubmed/28388673
http://dx.doi.org/10.1371/journal.pone.0174254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384750/
https://www.ncbi.nlm.nih.gov/pubmed/28388673
http://dx.doi.org/10.1371/journal.pone.0174254

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