Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response

Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity...

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Autores principales: Harris, Violaine K., Bell, Lena, Langan, Ruth-Anne, Tuddenham, John, Landy, Mark, Sadiq, Saud A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384772/
https://www.ncbi.nlm.nih.gov/pubmed/28388685
http://dx.doi.org/10.1371/journal.pone.0175575
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author Harris, Violaine K.
Bell, Lena
Langan, Ruth-Anne
Tuddenham, John
Landy, Mark
Sadiq, Saud A.
author_facet Harris, Violaine K.
Bell, Lena
Langan, Ruth-Anne
Tuddenham, John
Landy, Mark
Sadiq, Saud A.
author_sort Harris, Violaine K.
collection PubMed
description Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells. The upregulation of Fetuin-A in LPS-stimulated dendritic cells and microglia further supports an intrinsic role of Fetuin-A in regulating innate immune activation during EAE.
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spelling pubmed-53847722017-05-03 Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response Harris, Violaine K. Bell, Lena Langan, Ruth-Anne Tuddenham, John Landy, Mark Sadiq, Saud A. PLoS One Research Article Fetuin-A is a biomarker of disease activity in multiple sclerosis. Our aim was to investigate whether Fetuin-A plays a direct role in the neuroinflammatory response in the mouse EAE model. Peak Fetuin-A expression in the CNS and in peripheral lymphoid tissue correlated with peak EAE disease activity. Fetuin-A-deficient mice showed reduced EAE severity associated with an accumulation of splenic monocyte and dendritic cell populations, increased IL-12p40, ASC1, and IL-1β expression, and an increase in T regulatory cells. The upregulation of Fetuin-A in LPS-stimulated dendritic cells and microglia further supports an intrinsic role of Fetuin-A in regulating innate immune activation during EAE. Public Library of Science 2017-04-07 /pmc/articles/PMC5384772/ /pubmed/28388685 http://dx.doi.org/10.1371/journal.pone.0175575 Text en © 2017 Harris et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Harris, Violaine K.
Bell, Lena
Langan, Ruth-Anne
Tuddenham, John
Landy, Mark
Sadiq, Saud A.
Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title_full Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title_fullStr Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title_full_unstemmed Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title_short Fetuin-A deficiency protects mice from Experimental Autoimmune Encephalomyelitis (EAE) and correlates with altered innate immune response
title_sort fetuin-a deficiency protects mice from experimental autoimmune encephalomyelitis (eae) and correlates with altered innate immune response
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384772/
https://www.ncbi.nlm.nih.gov/pubmed/28388685
http://dx.doi.org/10.1371/journal.pone.0175575
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