SynthEx: a synthetic-normal-based DNA sequencing tool for copy number alteration detection and tumor heterogeneity profiling

Changes in the quantity of genetic material, known as somatic copy number alterations (CNAs), can drive tumorigenesis. Many methods exist for assessing CNAs using microarrays, but considerable technical issues limit current CNA calling based upon DNA sequencing. We present SynthEx, a novel tool for...

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Detalles Bibliográficos
Autores principales: Silva, Grace O., Siegel, Marni B., Mose, Lisle E., Parker, Joel S., Sun, Wei, Perou, Charles M., Chen, Mengjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385048/
https://www.ncbi.nlm.nih.gov/pubmed/28390427
http://dx.doi.org/10.1186/s13059-017-1193-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385048/
https://www.ncbi.nlm.nih.gov/pubmed/28390427
http://dx.doi.org/10.1186/s13059-017-1193-3

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