Cryo-EM structure of a separase-securin complex at near-atomic resolution

Separase is a caspase-family protease that initiates chromatid segregation by cleaving the kleisin subunits (Scc1 and Rec8) of cohesin, and regulates centrosome duplication and mitotic spindle function through cleavage of kendrin and Slk19. To understand the mechanisms of separase regulation by secu...

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Detalles Bibliográficos
Autores principales: Boland, Andreas, Martin, Thomas G., Zhang, Ziguo, Yang, Jing, Bai, Xiao-chen, Chang, Leifu, Scheres, Sjors H.W., Barford, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385133/
https://www.ncbi.nlm.nih.gov/pubmed/28263324
http://dx.doi.org/10.1038/nsmb.3386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385133/
https://www.ncbi.nlm.nih.gov/pubmed/28263324
http://dx.doi.org/10.1038/nsmb.3386

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