Pathological Role of Peptidyl-Prolyl Isomerase Pin1 in the Disruption of Synaptic Plasticity in Alzheimer's Disease

Synaptic loss is the structural basis for memory impairment in Alzheimer's disease (AD). While the underlying pathological mechanism remains elusive, it is known that misfolded proteins accumulate as β-amyloid (Aβ) plaques and hyperphosphorylated Tau tangles decades before the onset of clinical...

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Detalles Bibliográficos
Autores principales: Xu, Lingyan, Ren, Zhiyun, Chow, Frances E., Tsai, Richard, Liu, Tongzheng, Rizzolio, Flavio, Boffo, Silvia, Xu, Yungen, Huang, Shaohui, Lippa, Carol F., Gong, Yuesong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385220/
https://www.ncbi.nlm.nih.gov/pubmed/28458925
http://dx.doi.org/10.1155/2017/3270725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385220/
https://www.ncbi.nlm.nih.gov/pubmed/28458925
http://dx.doi.org/10.1155/2017/3270725

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