HILI destabilizes microtubules by suppressing phosphorylation and Gigaxonin-mediated degradation of TBCB

Human PIWIL2, aka HILI, is a member of PIWI protein family and overexpresses in various tumors. However, the underlying mechanisms of HILI in tumorigenesis remain largely unknown. TBCB has a critical role in regulating microtubule dynamics and is overexpressed in many cancers. Here we report that HI...

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Detalles Bibliográficos
Autores principales: Tan, Hao, Liao, Hua, Zhao, Lianfang, Lu, Yilu, Jiang, Siyuan, Tao, Dachang, Liu, Yunqiang, Ma, Yongxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385498/
https://www.ncbi.nlm.nih.gov/pubmed/28393858
http://dx.doi.org/10.1038/srep46376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385498/
https://www.ncbi.nlm.nih.gov/pubmed/28393858
http://dx.doi.org/10.1038/srep46376

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