Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection

Cell surface aminopeptidase N (APN) is a membrane-bound ectoenzyme that hydrolyzes proteins and peptides and regulates numerous cell functions. APN participates in tumor cell expansion and motility, and is a target for cancer therapies. Small drugs that bind to the APN active site inhibit catalysis...

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Detalles Bibliográficos
Autores principales: Santiago, César, Mudgal, Gaurav, Reguera, Juan, Recacha, Rosario, Albrecht, Sébastien, Enjuanes, Luis, Casasnovas, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385526/
https://www.ncbi.nlm.nih.gov/pubmed/28393915
http://dx.doi.org/10.1038/srep46045

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385526/
https://www.ncbi.nlm.nih.gov/pubmed/28393915
http://dx.doi.org/10.1038/srep46045

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