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Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor
Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA adducts. This enzyme is strongly induced by man...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385587/ https://www.ncbi.nlm.nih.gov/pubmed/28405246 http://dx.doi.org/10.1186/s41021-017-0076-x |