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Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor

Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P450 enzymes. Cytochrome P4501A1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA adducts. This enzyme is strongly induced by man...

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Detalles Bibliográficos
Autores principales:	Shiizaki, Kazuhiro, Kawanishi, Masanobu, Yagi, Takashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385587/ https://www.ncbi.nlm.nih.gov/pubmed/28405246 http://dx.doi.org/10.1186/s41021-017-0076-x

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