Capturing RNA Folding Free Energy with Coarse-Grained Molecular Dynamics Simulations

We introduce a coarse-grained RNA model for molecular dynamics simulations, RACER (RnA CoarsE-gRained). RACER achieves accurate native structure prediction for a number of RNAs (average RMSD of 2.93 Å) and the sequence-specific variation of free energy is in excellent agreement with experimentally m...

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Detalles Bibliográficos
Autores principales: Bell, David R., Cheng, Sara Y., Salazar, Heber, Ren, Pengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385882/
https://www.ncbi.nlm.nih.gov/pubmed/28393861
http://dx.doi.org/10.1038/srep45812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5385882/
https://www.ncbi.nlm.nih.gov/pubmed/28393861
http://dx.doi.org/10.1038/srep45812

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