Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage

This study highlights the possible pathological role of MMP-12 in the context of ischemic stroke. Male rats were subjected to a two-hour middle cerebral artery occlusion (MCAO) procedure. MMP-12 shRNA expressing plasmid formulation was administered to these rats twenty-four hours after reperfusion....

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Detalles Bibliográficos
Autores principales: Chelluboina, Bharath, Warhekar, Aditi, Dillard, Matt, Klopfenstein, Jeffrey D., Pinson, David M., Wang, David Z., Veeravalli, Krishna Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386183/
https://www.ncbi.nlm.nih.gov/pubmed/25955565
http://dx.doi.org/10.1038/srep09504

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386183/
https://www.ncbi.nlm.nih.gov/pubmed/25955565
http://dx.doi.org/10.1038/srep09504

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