The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagy

MK-8776 is a recently described inhibitor that is highly selective for checkpoint kinase 1 (Chk1), which can weaken the DNA repair capacity in cancer cells to achieve chemo-sensitization. A number of studies show that MK-8776 enhances the cytotoxicity of hydroxyurea and gemcitabine without increasin...

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Detalles Bibliográficos
Autores principales: Zhou, Zhi-rui, Yang, Zhao-zhi, Wang, Shao-jia, Zhang, Li, Luo, Ju-rui, Feng, Yan, Yu, Xiao-li, Chen, Xing-xing, Guo, Xiao-mao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386307/
https://www.ncbi.nlm.nih.gov/pubmed/28042876
http://dx.doi.org/10.1038/aps.2016.136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386307/
https://www.ncbi.nlm.nih.gov/pubmed/28042876
http://dx.doi.org/10.1038/aps.2016.136

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