H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

Long noncoding RNA-H19 (H19), an imprinted oncofetal gene, has a central role in carcinogenesis. Hitherto, the mechanism by which H19 regulates cancer stem cells, remains elusive. Here we show that breast cancer stem cells (BCSCs) express high levels of H19, and ectopic overexpression of H19 signifi...

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Detalles Bibliográficos
Autores principales: Peng, Fei, Li, Ting-Ting, Wang, Kai-Li, Xiao, Guo-Qing, Wang, Ju-Hong, Zhao, Hai-Dong, Kang, Zhi-Jie, Fan, Wen-Jun, Zhu, Li-Li, Li, Mei, Cui, Bai, Zheng, Fei-Meng, Wang, Hong-Jiang, Lam, Eric W-F, Wang, Bo, Xu, Jie, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386357/
https://www.ncbi.nlm.nih.gov/pubmed/28102845
http://dx.doi.org/10.1038/cddis.2016.438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386357/
https://www.ncbi.nlm.nih.gov/pubmed/28102845
http://dx.doi.org/10.1038/cddis.2016.438

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