Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice

Primary sclerosing cholangitis (PSC) is a cholestatic liver disease of unknown etiopathogenesis characterized by fibrous cholangiopathy of large and small bile ducts. Systemic administration of a murine TNF-related apoptosis-inducing ligand (TRAIL) receptor agonist induces a sclerosing cholangitis i...

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Detalles Bibliográficos
Autores principales: Guicciardi, Maria Eugenia, Krishnan, Anuradha, Bronk, Steven F, Hirsova, Petra, Griffith, Thomas S, Gores, Gregory J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386369/
https://www.ncbi.nlm.nih.gov/pubmed/28055006
http://dx.doi.org/10.1038/cddis.2016.459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386369/
https://www.ncbi.nlm.nih.gov/pubmed/28055006
http://dx.doi.org/10.1038/cddis.2016.459

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