Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2

Sponges of the porifera family harbor some of the evolutionary most ancient orthologs of the B-cell lymphoma-2 (Bcl-2) family, a protein family critical to regulation of apoptosis. The genome of the sponge Geodia cydonium contains the putative pro-survival Bcl-2 homolog BHP2, which protects sponge t...

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Detalles Bibliográficos
Autores principales: Caria, Sofia, Hinds, Mark G, Kvansakul, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386376/
https://www.ncbi.nlm.nih.gov/pubmed/28079890
http://dx.doi.org/10.1038/cddis.2016.469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386376/
https://www.ncbi.nlm.nih.gov/pubmed/28079890
http://dx.doi.org/10.1038/cddis.2016.469

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