Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and is one of the leading causes of cancer-related death worldwide. Simvastatin, an HMG-CoA reductase inhibitor, which decreases cholesterol synthesis by inhibiting mevalonate pathways and is widely used to treat cardiovascular dise...

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Detalles Bibliográficos
Autores principales: Wang, Sin-Ting, Ho, Hsiu J, Lin, Jaw-Town, Shieh, Jeng-Jer, Wu, Chun-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386458/
https://www.ncbi.nlm.nih.gov/pubmed/28230855
http://dx.doi.org/10.1038/cddis.2016.472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386458/
https://www.ncbi.nlm.nih.gov/pubmed/28230855
http://dx.doi.org/10.1038/cddis.2016.472

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