Rapamycin upregulates glutamate transporter and IL-6 expression in astrocytes in a mouse model of Parkinson's disease

Rapamycin protects mice against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced loss of dopaminergic neurons, which is an established model for Parkinson's disease. We demonstrated that rapamycin preserves astrocytic expression of glutamate transporters and glutamate reuptake. The p...

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Detalles Bibliográficos
Autores principales: Zhang, Yunlong, He, Xiaoliang, Wu, Xiaojuan, Lei, Ming, Wei, Zhiyun, Zhang, Xiuping, Wen, Lei, Xu, Pingyi, Li, Shaomin, Qu, Shaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386462/
https://www.ncbi.nlm.nih.gov/pubmed/28182002
http://dx.doi.org/10.1038/cddis.2016.491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386462/
https://www.ncbi.nlm.nih.gov/pubmed/28182002
http://dx.doi.org/10.1038/cddis.2016.491

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