TAK1 regulates resident macrophages by protecting lysosomal integrity

Hematopoietic cell survival and death is critical for development of a functional immune system. Here, we report that a protein kinase, TAK1, is selectively required for resident macrophage integrity during embryogenesis. Hematopoietic lineage-specific deletion of Tak1 gene (Tak1(HKO)) caused accumu...

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Detalles Bibliográficos
Autores principales: Sakamachi, Yosuke, Morioka, Sho, Mihaly, September R, Takaesu, Giichi, Foley, Julie F, Fessler, Michael B, Ninomiya-Tsuji, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386472/
https://www.ncbi.nlm.nih.gov/pubmed/28182011
http://dx.doi.org/10.1038/cddis.2017.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386472/
https://www.ncbi.nlm.nih.gov/pubmed/28182011
http://dx.doi.org/10.1038/cddis.2017.23

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