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Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence
Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell (MSC) monolayer sheet transplantation on allograft repair. A limiting factor in their application is the loss of MSC multi-potency as a result of high density sheet culture-induced senescence. In the study reported...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386477/ https://www.ncbi.nlm.nih.gov/pubmed/28151468 http://dx.doi.org/10.1038/cddis.2017.2 |