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Notch activation enhances mesenchymal stem cell sheet osteogenic potential by inhibition of cellular senescence

Our previous studies have confirmed the therapeutic effects of mesenchymal stem cell (MSC) monolayer sheet transplantation on allograft repair. A limiting factor in their application is the loss of MSC multi-potency as a result of high density sheet culture-induced senescence. In the study reported...

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Detalles Bibliográficos
Autores principales:	Tian, Ye, Xu, Ying, Xue, Taiyang, Chen, Longgang, Shi, Bin, Shu, Bing, Xie, Chao, Max Morandi, Massimo, Jaeblon, Todd, Marymont, John V, Dong, Yufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386477/ https://www.ncbi.nlm.nih.gov/pubmed/28151468 http://dx.doi.org/10.1038/cddis.2017.2

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